All posts by Eric Olson
Blending of Log Normal Particle Size Distribution Data from Multiple Image Analyses Into Single Continuous Data Set
ABSTRACT Image analysis is one method by which particle size may be measured. In many cases, it is considered the “gold standard” of particle size measurement and is often used to verify the results of other techniques. Sample
Particle Shape Factors and Their Use in Image Analysis Part II: Practical Applications
ABSTRACT The first installment of this two-part discussion concluded by stating a single linear measurement (i.e., circular equivalent diameter) may not be adequate to describe a typical non-spherical particle with some degree of surface roughness. There are various
Particle Shape Factors and Their Use in Image Analysis – Part 1: Theory
ABSTRACT Fine particles are often characterized by their particle size and distribution as determined by various analytical instruments. Particle shape may be just as important as particle size. Particle shape, however, is often ignored or disregarded. Image analysis
The Importance of Sample Preparation When Measuring Specific Surface Area
ABSTRACT Specific surface area is a fundamental measurement in the field of fine particle characterization. Specific surface area measurements have numerous pharmaceutical manufacturing and quality applications. Compliance professionals should have a general understanding of the principles, procedures, and
Zeta Potential and Colloid Chemistry
ABSTRACT The US Food and Drug Administration often requests the measurement of zeta potential; however, there is virtually no guidance offered in any of the regulatory pharmacopoeias. Guidelines are available in other standards, and there exists a wealth